Common Causes of Glomerular Disease

Diseases caused due to Glomerulus can range from acute to chronic diseases.  Acute illnesses caused due to it could be infections of upper respiratory system which can be self resolved or at extreme level or at Chronic level the diseases caused could be HIV. In some cases progressive renal failure can also occur due to the systematic lupus erythematous. There are two major types of syndromes of Glomerulonephritis. The two types are nephrotic and nephritic syndromes. The diseases in Nephrotic syndromes are Minimal Change Disease (MCD), Membranous Nephropathy (MN), Focal Segmental Glomerulosclerosis (FSG) and Membranoproliferative Glomerulonephritis  (MPGN). The diseases in Nephritic Syndromes are Post Streptoccocal Glomerulonephritis (PSGS), igA Nephropathy, Henoch-Shconlein Purpura (HSP) and rapidly progressive GN (RGN types 1, 2, 3).

Now let us have a look at Nephrotic Diseases. MCD is found more in children as compared to adults. Those who are prone to allergies are mostly affected by it. Mostly it is caused due to NSAID use and Hodgkin’s Lymphoma. This can be treated with the help of steroids. Steroids used here can be Cyclophosphamide and cyclosporine. FSG is very common in United States of America and FSG is the most common reason of occurrence of Nephrotic syndrome in the black people in USA.  Most common causes of its occurrence are due to HIV, sickle cell disease, parvovirus B19, obesity, heroin use and chronic vesicoureteral reflux.  Treatment of this can be made with the help of steroids. Steroids which can be used are Cyclosporine and mycophenolate mofetil. MN is common in both men and women. Ratio of MN is double in men as compared to women. The Adult onset idiopathic nephritic syndrome is due to this. It commonly causes the disorder in renal vein thrombosis. Steroids are consumed for its treatment. Apart from steroids cytotoxic therapy is also used as treatment. MPGN is common among the adults and also in the children. It can be connected with Hepatitis C but there are other diseases as well and that is the main reason why its treatment depend upon the disease associated.

Now let us have a look at the Nephritic Diseases. PSGN in it is normally linked with the infections of skin and throat. Color of urine becomes smoky and dark. A supportive treatment is done for it. IgA Nephropathy is a universal disease. It can occur in both males and females but mostly it occurs in males. It normally occurs when someone has just recovered from the upper infection of respiratory system. It can be treated with steroids and alkalyting agents. Other syndromes such as HSP and RGN can also be treated with the help of Steroids like cyclophosphamide (depending on condition) and plasmapharesis.

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